Synthesis, Characterisation and Anti-inflammatory Activity of Some 2-amino Benzothiazole Derivatives

A series of some novel 2-amino benzothiazole derivatives were synthesized and evaluated for antiinflammatory activity. The titled compounds were synthesized from the substituted aromatic amines through the intermediate substituted 1-phenylthiourea oxidation by bromine water in acidic medium. The purity of the synthesized compounds were judged by their C, H and N analysis and the structure was analyzed on the basis of IR, HNMR and Mass spectral data. The anti-inflammatory activities of new compounds were determined by λ-Carrageenan-induced mice paw edema method using diclofenac sodium as a standard. Among the compounds tested three compounds Bt2 (5chloro-1,3-benzothiazole-2-amine), Bt (6-methoxy-1,3-benzothiazole-2-amine) and Bt7 (6-methoxy-1,3-benzothiazole2-amine)were the most active compounds in these series when compared with diclofenac sodium. In the SAR study, the phenyl ring substituted with chloro at 5 position, methoxy substitution at 4 and 6-position in benzothiazole ring system showed better anti-inflammatory activity.